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  "_id": "6a23cb4c530b9bc726be189c",
  "Package": "scModels",
  "Title": "Fitting Discrete Distribution Models to Count Data",
  "Version": "1.0.5",
  "DateNote": "Previous CRAN version 1.0.4 on 2023-01-23",
  "Maintainer": "Kumar Harsha <kumarharsha.0292@gmail.com>",
  "Authors@R": "c(\nperson(\"Lisa\", \"Amrhein\",\nemail=\"amrheinlisa@gmail.com\",\nrole=\"aut\",\ncomment=c(ORCID=\"0000-0002-0370-624X\")),\nperson(\"Kumar\", \"Harsha\",\nemail=\"kumarharsha.0292@gmail.com\",\nrole=c(\"aut\", \"cre\"),\ncomment=c(ORCID=\"0000-0002-3865-5286\")),\nperson(\"Christiane\", \"Fuchs\",\nemail=\"christiane.fuchs@helmholtz-muenchen.de\",\nrole=\"aut\",\ncomment=c(ORCID=\"0000-0003-3565-8315\")),\nperson(\"Pavel\", \"Holoborodko\",\nemail=\"pavel@holoborodko.com\",\nrole=\"ctb\",\ncomment=\"Author and copyright holder of 'mpreal.h'\"))",
  "License": "GPL-3",
  "Description": "Provides functions for fitting discrete distribution\nmodels to count data. Included are the Poisson, the negative\nbinomial, the Poisson-inverse gaussian and, most importantly, a\nnew implementation of the Poisson-beta distribution (density,\ndistribution and quantile functions, and random number\ngenerator) together with a needed new implementation of\nKummer's function (also: confluent hypergeometric function of\nthe first kind). Three different implementations of the\nGillespie algorithm allow data simulation based on the basic,\nswitching or bursting mRNA generating processes. Moreover,\nlikelihood functions for four variants of each of the three\naforementioned distributions are also available. The variants\ninclude one population and two population mixtures, both with\nand without zero-inflation. The package depends on the 'MPFR'\nlibraries (<https://www.mpfr.org/>) which need to be installed\nseparately (see description at\n<https://github.com/fuchslab/scModels>). This package is\nsupplement to the paper \"A mechanistic model for the negative\nbinomial distribution of single-cell mRNA counts\" by Lisa\nAmrhein, Kumar Harsha and Christiane Fuchs (2019)\n<doi:10.1101/657619> available on bioRxiv.",
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  "Packaged": {
    "Date": "2026-06-06 07:16:18 UTC",
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  "Author": "Lisa Amrhein [aut] (ORCID:\n<https://orcid.org/0000-0002-0370-624X>), Kumar Harsha [aut,\ncre] (ORCID: <https://orcid.org/0000-0002-3865-5286>),\nChristiane Fuchs [aut] (ORCID:\n<https://orcid.org/0000-0003-3565-8315>), Pavel Holoborodko\n[ctb] (Author and copyright holder of 'mpreal.h')",
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  "Repository": "https://hkumar6.r-universe.dev",
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    "extra/citation.json",
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    "gmRNA_basic",
    "gmRNA_basic_burst",
    "gmRNA_burst",
    "gmRNA_IGbasic_burst",
    "gmRNA_switch",
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    "nlogL_zidel2",
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    "nlogL_zinb2",
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    "nlogL_zipb2",
    "nlogL_zipig",
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    "nlogL_zipois",
    "nlogL_zipois2",
    "ppb",
    "qpb",
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    "rpb"
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      "title": "Kummer's (confluent hypergeometric) function in log-scale",
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      "title": "Functions to estimate parameters of probability distributions by fitting the distributions using optim()",
      "topics": [
        "fit_params"
      ]
    },
    {
      "page": "gmRNA",
      "title": "Gillespie algorithm for mRNA generating processes",
      "topics": [
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        "gmRNA_basic",
        "gmRNA_basic_burst",
        "gmRNA_burst",
        "gmRNA_IGbasic_burst",
        "gmRNA_switch"
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      "title": "Inverse Gaussian Distribution",
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        "rInvGaus"
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        "nlogL_del",
        "nlogL_del2",
        "nlogL_nb",
        "nlogL_nb2",
        "nlogL_pb",
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